Peer reviewed publications using the Way To Health platform

Innovative research and evidence based publications

J Gen Intern Med

Partners and Alerts in Medication Adherence: A Randomized Clinical Trial

Mar 2018
Kessler JB, Troxel AB, Asch DA, Mehta SJ, Marcus N, Lim R, Zhu J, Shrank W, Brennan T, Volpp KG

Automated alerts were effective at improving medication adherence. Assigning a medication adherence partner did not statistically significantly affect adherence rates.

Am J Health Promot.

A Randomized, Controlled Trial of Lottery-Based Financial Incentives to Increase Physical Activity Among Overweight and Obese Adults

Jan 2018
Patel MS, Volpp KG, Rosin R, Bellamy SL, Small DS, Heuer J, Sproat S, Hyson C, Haff N, Lee SM, Wesby L, Hoffer K, Shuttleworth D, Taylor DH, Hilbert V, Zhu J, Yang L, Wang X, Asch DA

Combined lottery incentives were most effective in increasing physical activity

JAMA Pediatr.

Effect of Financial Incentives on Glucose Monitoring Adherence and Glycemic Control Among Adolescents and Young Adults With Type 1 Diabetes

Oct 2017
Charlene A. Wong, MD, MSHP; Victoria A. Miller, PhD; Kathryn Murphy, PhD; Dylan Small, PhD; Carol A. Ford, MD; Steven M. Willi, MD; Jordyn Feingold, MAPP; Alexander Morris, BS; Yoonhee P. Ha, MSc, MPhil; Jingsan Zhu, MS, MBA2; Wenli Wang, MS2; Mitesh S. Patel, MD, MBA, MS2

In a randomized clinical trial including 90 adolescents and young adults with poorly controlled type 1 diabetes, daily financial incentives improved glucose monitoring in the intervention group (50.0%) vs the control group (18.9%) but did not affect their glycemic control. Financial incentives showed promise for improving glucose monitoring behaviors among adolescents and young adults with type 1 diabetes

JAMA Intern Med.

Effect of Electronic Reminders, Financial Incentives, and Social Support on Outcomes After Myocardial Infarction: The HeartStrong Randomized Clinical Trial

Jun 2017
Kevin G. Volpp, MD, PhD; Andrea B. Troxel, ScD6; Shivan J. Mehta, MD, MBA, MSHP; Laurie Norton, MA; Jingsan Zhu, MS, MBA; Raymond Lim, MA; Wenli Wang, MS; Noora Marcus, MA; Christian Terwiesch, PhD; Kristen Caldarella, MHA; Tova Levin, MBA; Mike Relish, MA; Nathan Negin, MD; Aaron Smith-McLallen, PhD; Richard Snyder, MD; Claire M. Spettell, PhD; Brian Drachman, MD; Daniel Kolansky, MD; David A. Asch, MD, MBA

In this randomized clinical trial of 1509 patients following acute myocardial infarction, there were no statistically significant differences between study arms in time to first rehospitalization for a vascular event or death, medication adherence, or cost.

J Beh Med

Time to selected quit date and subsequent rates of sustained smoking abstinence

Jun 2017
George L. Anesi, Scott D. Halpern, Michael O. Harhay, Kevin G. Volpp, Kathryn Saulsgiver

In efforts to combat tobacco dependence, most smoking cessation programs offer individuals who smoke the choice of a target quit date. However, it is uncertain whether the time to the selected quit date is associated with participants’ chances of achieving sustained abstinence. In a pre-specified secondary analysis of a randomized clinical trial of four financial-incentive programs or usual care to encourage smoking cessation (Halpern et al. in N Engl J Med 372(22):2108–2117, doi:10.1056/NEJMoa1414293, 2015), study participants were instructed to select a quit date between 0 and 90 days from enrollment. Among those who selected a quit date and provided complete baseline data (n = 1848), we used multivariable logistic regression to evaluate the association of the time to the selected quit date with 6- and 12-month biochemically-confirmed abstinence rates. In the fully adjusted model, the probability of being abstinent at 6 months if the participant selected a quit date in weeks 1, 5, 10, and 13 were 39.6, 22.6, 10.9, and 4.3%, respectively.

J Gen Intern Med

Patient and Partner Feedback Reports to Improve Statin Medication Adherence: A Randomized Control Trial

Mar 2017
Ashok Reddy, Tiffany L. Huseman, Anne Canamucio, Steven C. Marcus, David A. AschK, evin Volpp, Judith A. Long

Simple nudges such as reminders and feedback reports to either a patient or a partner may facilitate improved medication adherence.

Am. J. Kidney Dis.

Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial

Mar 2017
Peter P. Reese, MD, MSCE, Roy D. Bloom, MD, Jennifer Trofe-Clark, PharmD, Adam Mussell, MA, Daniel Leidy, BA, Simona Levsky, BS, Jingsan Zhu, MS, MBA, Lin Yang, MS, Wenli Wang, MS, Andrea Troxel, ScD, Harold I. Feldman, MD, MSCE, Kevin Volpp, MD, PhD

Provider notification and customized reminders appear promising in helping patients achieve better medication adherence, but these strategies require evaluation in trials powered to detect differences in clinical outcomes

Am J Prev Med.

A Trial of Financial and Social Incentives to Increase Older Adults' Walking

Mar 2017
Kristin A.HarkinsBA, Jeffrey T.Kullgren MD, MS, MPH; Scarlett L.Bellamy ScD; Jason Karlawish MD; Karen Glanz PhD, MPH

Incentive schemes that use donations to a charity of choice, personal financial incentives, or a combination of the two can each increase older adults’ initial uptake of increased levels of walking.

J of Clin Out Mgmt.

Rapid-Cycle Innovation Testing of Text-Based Monitoring for Management of Postpartum Hypertension

Feb 2017
Adi Hirshberg,MD, Marianne D. Bittle,MSN,RNC–OB, Matthew VanDerTuyn,MID, Katy Mahraj,MSI, David A. Asch,MD,MBA, Roy Rosin,MBA, Ian Bennett,MD,PhD, Sindhu K. Srinivas,MD,MSCE

Our results suggest that remote blood pressure monitoring via text message communication engages patients and shows promise as a convenient and effective means of hypertension surveillance in the immediate postpartum period, in accordance to ACOG guidelines


Physician attitudes toward participating in a financial incentive program for LDL reduction are associated with patient outcomes

Dec 2016
Tianyu Liu, David A.Asch, Kevin G.Volpp, Jingsan Zhu, Wenli Wang, Andrea B.Troxel, Aderinola Adejare, Darra D.Finnerty, Karen Hoffer, Judy A.Shea

In primary care practices, shared financial incentives for physicians and patients, but not incentives to physicians or patients alone, resulted in a statistically significant difference in reduction of LDL-C levels at 12 months. This reduction was modest, however, and further information is needed to understand whether this approach represents good value